In short, the C-5 can carry the most cargo the furthest. Its max weight is 840,000 pounds. It can carry the most cargo of any US airlifter. Last fall, as part of a retrograde operation to bring cargo and equipment out of Afghanistan, each C-5 was setting record payloads, with the heaviest being 280,880 pounds. Overall 25.5 million pounds of cargo and 447 passengers were moved on 152 missions.